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List of clinical trials using CIK cells:
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Cai LL, Yang Y, Yang B, Zhu HL, Lu XC, Zhang WY, Yu RL, Chi XH, Wang Y, Dai HR, Han WD, Fan H, Li SX, Liu Y, Ran HH, Lin J, Tuo S, Tuo CW, Zhang F, Cao JP, Yao SQ.

Short-term curative efficacy of autologous cytokine induced killer cells combined with low-dose IL-2 regimen containing immune enhancement by thymic peptide in elderly patients with B-cell chronic lymphocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):564-70.

 

Chang XH, Cheng HY, Cheng YX, Ye X, Guo HF, Fu TY, Zhang L, Zhang G, Cui H. Specific immune cell therapy against ovarian cancer in vivo and in vitro.  Ai Zheng (2008) 27(12):1244-50.

 

Chen FX, Liu JQ, Zhang NZ, Gong XJ, Zhang GL, Xu YM, Zhou ZH, Wang T, Huang J.
[Clinical observation on adoptive immunotherapy with autologous cytokine-induced killer cells for advanced malignant tumor] Ai Zheng. 2002 Jul;21(7):797-801. Chinese.

 

Ge W, Li CH, Zhang W, Han Q, Deng WM, Chen L, You SG, Zhao CH
Coculture of dendritic cell with cytokine-induced killer results in a significant increase in cytotoxic activity of CIK to tumor cells in vitro and in vivo.  Zhonghua Xue Ye Xue Za Zhi (2004) 25(5):277-80.

 

Gao D, Li C, Xie X, Zhao P, Wei X, Sun W, Liu HC, Alexandrou AT, Jones J, Zhao R, Li JJ.

Autologous tumor lysate-pulsed dendritic cell immunotherapy with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients. PLoS One. 2014 Apr 3;9(4):e93886.

 

Hao MZ, Lin HL, Chen Q, Ye YB, Chen QZ, Chen MS.

Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study. Chin J Cancer. 2010 Feb;29(2):172-7.

 

Hontscha C, Borck Y, Zhou H, Messmer D, Schmidt-Wolf IG. Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol. 2011 Feb;137(2):305-10.

 

Huang HQ, Cai QC, Shi YX, Lin XB, Wei J, Guo Y, Pan ZH.

Preliminary assessment of immune reconstitution after autologous peripheral hematopoietic stem cell transplantation (AHSCT). Ai Zheng. 2006 Aug;25(8):1023-8.

 

Hui D, Qiang L, Jian W, Ti Z, Da-Lu K. A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma.

Dig Liver Dis. 2009 Jan;41(1):36-41.

 

Introna M, Borleri G, Conti E, Franceschetti M, Barbui AM, Broady R, Dander E, Gaipa G, D'Amico G, Biagi E, Parma M, Pogliani EM, Spinelli O, Baronciani D, Grassi A, Golay J, Barbui T, Biondi A, Rambaldi A. Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study. Haematologica. 2007 Jul;92(7):952-9.

 

Introna M, Pievani A, Borleri G, Capelli C, Algarotti A, Micò C, Grassi A, Oldani E, Golay J, Rambaldi A.

Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation.

Biol Blood Marrow Transplant. 2010 Nov;16(11):1603-7

 

Jiang H, Liu KY, Tong CR, Jiang B, Lu DP.´The efficacy of chemotherapy in combination with auto-cytokine-induced killer cells in acute leukemia. Zhonghua Nei Ke Za Zhi. 2005 Mar;44(3):198-201.

 

Jiang H, Liu KY, Tong CR, Jiang B, Lu DP. The efficacy of chemotherapy in combination with auto-cytokine-induced killer cells in acute leukemia. Zhonghua Nei Ke Za Zhi. 2005 Mar;44(3):198-201.

 

Jiang J, Xu N, Wu C, Deng H, Lu M, Li M, Xu B, Wu J, Wang R, Xu J, Nilsson-Ehle P.

Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res. 2006 May-Jun;26(3B):2237-42.

 

Jiang JT, Shen YP, Wu CP, Zhu YB, Wei WX, Chen LJ, Zheng X, Sun J, Lu BF, Zhang XG.
Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients. World J Gastroenterol (2010) 16(48):6155-62.

 

Kim HM, Lim J, Kang JS, Park SK, Lee K, Kim JY, Kim YJ, Hong JT, Kim Y, Han SB
Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model.  Int Immunopharmacol (2009) 9(3):375-80.

 

Kim HM, Lim J, Park SK, Kang JS, Lee K, Lee CW, Lee KH, Yun MJ, Yang KH, Han G, Kwon SW, Kim Y, Han SB. Antitumour activity of cytokine- induced killer cells against human lung cancer. 

Int Immunopharmacol (2007) 7(13):1802-7.

 

Kim HM, Lim J, Yoon YD, Ahn JM, Kang JS, Lee K, Park SK, Jeong YJ, Kim JM, Han G, Yang KH, Kim YJ, Kim Y, Han SB. Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.  Int Immunopharmacol (2007) 7(13):1793-801.



Kim HM, Kang JS, Lim J, Kim JY, Kim YJ, Lee SJ, Song S, Hong JT, Kim Y, Han SB
Antitumor activity of cytokine-induced killer cells in nude mouse xenograft models. 

Arch Pharm Res (2009) 32(5):781-7.



Kim HM, Kang JS, Lim J, Park SK, Lee K, Yoon YD, Lee CW, Lee KH, Han G, Yang KH, Kim YJ, Kim Y, Han SB. Inhibition of human ovarian tumor growth by cytokine-induced killer cells. 

Arch Pharm Res (2007) 30(11):1464-70.



Kornacker M, Verneris M, Kornacker B, Ganten T, Scheffold C, Negrin R.
The apoptotic and proliferative fate of cytokine-induced killer cells after redirection to tumor cells with bispecific Ab.  Cytotherapy. 2006;8(1):13-23.

 

 

Leemhuis T, Wells S, Scheffold C, Edinger M, Negrin RS.

A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2005 Mar;11(3):181-7.

 

Lei K, Wang J, Jia Y, Xiong Y, Yuan Z. The effects of CIK cells on the treatment of renal cell carcinoma.  Chinese-German Journal of Clinical Oncology (2009) 8(6):346-348.

 

Li R, Wang C, Liu L, Du C, Cao S, Yu J, Wang SE, Hao X, Ren X, Li H.

Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study.

Cancer Immunol Immunother. 2012 Nov;61(11):2125-33

 

Lin J, Zhu H, Lu X, Yang B, Han W, Dai H, Wang Y.
Autologous cytokine-induced killer cells in the treatment of multiple myeloma concomitant with lung cancer and paraneoplastic dermatoses. Intern Med  (2010) 49(21):2341-2346.

 

Linn YC, Niam M, Chu S, Choong A, Yong HX, Heng KK, Hwang W, Loh Y, Goh YT, Suck G, Chan M, Koh M. The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies. Bone Marrow Transplant. 2012 Jul;47(7):957-66

 

Liu H, Song J, Yang Z, Zhang X.

Effects of cytokine-induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery. Exp Ther Med. 2013 Oct;6(4):953-956.

 

Liu J, Li H, Cao S, Zhang X, Yu J, Qi J, An X, Yu W, Ren X, Hao X.

Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment. J Immunother. 2014 Feb-Mar;37(2):115-22.

 

Liu L, Zhang W, Qi X, Li H, Yu J, Wei S, Hao X, Ren X.

Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clin Cancer Res. 2012 Mar 15;18(6):1751-9.

 

Liu Y, Bao EN, Yang B, Lu XC, Zhu HL, Han WD, Wang Y, Dai HR, Yao SQ.

Clinical study of autologous cytokine induced killer cell infusion treating for elderly patients with myelodysplastic syndrome. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):787-92.

 

Lu XC, Yang B, Yu RL, Chi XH, Tuo S, Tuo CW, Zhu HL, Wang Y, Jiang CG, Fu XB, Yang Y, Liu Y, Yao SQ, Dai HR, Cai L, Li BJ, Han WD.

Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma. Cell Biochem Biophys. 2012 Jan;62(1):257-65

 

Niu Q, Wang W, Li Y, Qin S, Wang Y, Wan G, Guan J, Zhu W. Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies. Int Immunopharmacol. 2011 Apr;11(4):449-56.

 

Olioso P, Giancola R, Di Riti M, Contento A, Accorsi P, Iacone A.

Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: a pilot clinical trial. Hematol Oncol. 2009 Sep;27(3):130-9.

 

Pan K, Guan XX, Li YQ, Zhao JJ, Li JJ, Qiu HJ, Weng DS, Wang QJ, Liu Q, Huang LX, He J, Chen SP, Ke ML, Zeng YX, Xia JC.

Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer. Clin Cancer Res. 2014 Jun 1;20(11):3003-11.

 

Pan K, Li YQ, Wang W, Xu L, Zhang YJ, Zheng HX, Zhao JJ, Qiu HJ, Weng DS, Li JJ, Wang QJ, Huang LX, He J, Chen SP, Ke ML, Wu PH, Chen MS, Li SP, Xia JC, Zeng YX.

The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients. Ann Surg Oncol. 2013 Dec;20(13):4305-11.

 

Qiu Y, Xu MB, Yun MM, Wang YZ, Zhang RM, Meng XK, Ou-Yang XH, Yun S.

Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells. World J Gastroenterol. 2011 Dec 28;17(48):5260-6.

 

Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M, Cignetti A.
Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation.  Expert Opin Biol Ther. 2009 Jul;9(7):831-40.

 

Schmeel LC, Schmeel FC, Coch C, Schmidt-Wolf IG.

Cytokine-induced killer (CIK) cells in cancer immunotherapy: report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol. 2014 Nov 8.

 

Schmidt-Wolf IG, Finke S, Trojaneck B, Denkena A, Lefterova P, Schwella N, Heuft HG, Prange G, Korte M, Takeya M, Dorbic T, Neubauer A, Wittig B, Huhn D. Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br J Cancer. 1999 Nov;81(6):1009-16.

 

Shi L, Zhou Q, Wu J, Ji M, Li G, Jiang J, Wu C.

Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother. 2012 Dec;61(12):2251-9

 

Shi M, Zhang B, Tang ZR, Lei ZY, Wang HF, Feng YY, Fan ZP, Xu DP, Wang FS.

Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma. World J Gastroenterol. 2004 Apr 15;10(8):1146-51.

 

Shi M, Fu J, Shi F, Zhang B, Tang Z, Jin L, Fan Z, Zhang Z, Chen L, Wang H, Lau GK, Wang FS.
Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection.  Clin Immunol. 2009 Jul;132(1):43-54.

 

Shi M, Yao L, Wang FS, Lei ZY, Zhang B, Li WL, Liu JC, Tang ZR, Zhou GD
Growth inhibition of human hepatocellular carcinoma xenograft in nude mice by combined treatment with human cytokine-induced killer cells and chemotherapy. 

Zhonghua Zhong Liu Za Zhi (2004) 26(8):465-8.

 

Shi SB, Ma TH, Li CH, Tang XY. Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer. Tumori. 2012 May-Jun;98(3):314-9

 

Shi X, Ruan D, Wang Y, Ma L, Li M
Anti-tumor activity of safflower polysaccharide (SPS) and effect on cytotoxicity of CTL cells, NK cells of T739 lung cancer in mice. Zhongguo Zhong Yao Za Zhi (2010) 35(2):215-8.

 

Su HB, Li HW, Zhao HL, Shi M, Zhang B, Tang ZR, Lei ZY, Wang HF, Wang FS.
[Therapeutic effect of autologous cytokine-induced killer cells on patients with liver cirrhosis caused by HBV infection]  Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Mar;21(1):64-6.

 

Su X, Zhang L, Jin L, Ye J, Guan Z, Chen R, Guo T. Immunotherapy with cytokine-induced killer cells in metastatic renal cell carcinoma. Cancer Biother Radiopharm. 2010 Aug;25(4):465-70

 

Wang D, Zhang B, Gao H, Ding G, Wu Q, Zhang J, Liao L, Chen H. Clinical research of genetically modified dendritic cells in combination with cytokine-induced killer cell treatment in advanced renal cancer. BMC Cancer. 2014 Apr 10;14:251

 

Wang FS, Liu MX, Zhang B, Shi M, Lei ZY, Sun WB, Du QY, Chen JM
Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World J Gastroenterol (2002) 8(3):464-8.

 

Wang H, Zhou FJ, Wang QJ, Qin ZK, Huang LX, Liu ZW, Han H, Li YQ, Chen SP, Xia JC. [Efficacy of autologous renal tumor cell lysate-loaded dendritic cell vaccine in combination with cytokine-induced killer cells on advanced renal cell carcinoma--a report of ten cases]. Ai Zheng (2006) 25(5):625-30.

 

Wang P, Yu JP, Gao SY, An XM, Ren XB, Wang XG, Li WL.

Experimental study on the treatment of intracerebral glioma xenograft with human cytokine-induced killer cells. Cell Immunol (2008) 253(1-2):59-65.

 

Wang Y, Bo J, Dai HR, Lu XC, Lv HY, Yang B, Wang T, Han WD. CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo.

Exp Hematol. 2013 Mar;41(3):241-52.e3.

 

Wang Z, Zhang Y, Liu Y, Wang L, Zhao L, Yang T, He C, Song Y, Gao Q.

Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients. J Immunother. 2014 Jan;37(1):43-50.

 

Weng DS, Zhou J, Zhou QM, Zhao M, Wang QJ, Huang LX, Li YQ, Chen SP, Wu PH, Xia JC.
Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas.  J Immunother. 2008 Jan;31(1):63-71.

 

Wongkajornsilp A, Somchitprasert T, Butraporn R, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Maneechotesuwan K, Hongeng S.
Human cytokine-induced killer cells specifically infiltrated and retarded the growth of the inoculated human cholangiocarcinoma cells in SCID mice.  Cancer Invest. 2009 Feb;27(2):140-8.



Wu C, Jiang J, Shi L, Xu N.

Prospective study of chemotherapy in combination with cytokine-induced killer cells in patients suffering from advanced non-small cell lung cancer. Anticancer Res. 2008 Nov-Dec;28(6B):3997-4002.

 

Yang B, Lu XC, Yu RL, Chi XH, Liu Y, Wang Y, Dai HR, Zhu HL, Cai LL, Han WD.

Repeated transfusions of autologous cytokine-induced killer cells for treatment of haematological malignancies in elderly patients: a pilot clinical trial. Hematol Oncol. 2012 Sep;30(3):115-22.

 

Yang B, Lu XC, Zhu HL, Han WD, Wang Y, Fan H, Li SX, Liu Y, Dai HR, Yao SQ. Clinical study of autologous cytokine induced killer cells combined with IL-2 for therapy of elderly patients with B-cell malignant lymphoma. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Oct;18(5):1244-9.

 

Yang B, Wang J, Cai LL, Zhu HL, Yu RL, Chi XH, Lu XC. Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells. Cytotherapy. 2014 Feb;16(2):278-84.

 

Yang L, Ren B, Li H, Yu J, Cao S, Hao X, Ren X.

Enhanced antitumor effects of DC-activated CIKs to chemotherapy treatment in a single cohort of advanced non-small-cell lung cancer patients. Cancer Immunol Immunother. 2013 Jan;62(1):65-73

 

Yang XJ, Huang JA, Lei W, Zhu YB, Zhang XG. Antitumor effects of cocultured dendritic cells and cytokine-induced killer cells on lung cancer in vitro and in vivo.  Ai Zheng (2006) 25(11):1329-33.

 

Yang Y, Yang B, Cai LL, Ran HH, Yu RL, Chi XH, Zhu HL, Li SX, Liu Y, Wang Y, Han WD, Yao SQ, Lu XC.

Clinical study of autologous cytokine induced killer cells combined with chemotherapy for elderly patients with acute myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Feb;22(1):58-63

 

Yu X, Zhao H, Liu L, Cao S, Ren B, Zhang N, An X, Yu J, Li H, Ren X.

A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocellular carcinoma. J Clin Immunol. 2014 Feb;34(2):194-203.

 

Zhan HL, Gao X, Pu XY, Li W, Li ZJ, Zhou XF, Qiu JG. A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma. Chin Med J (Engl). 2012 Nov;125(21):3771-7.

 

Zhang J, Zhu L, Wei J, Liu L, Yin Y, Gu Y, Shu Y.

The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study. J Cancer Res Clin Oncol. 2012 Jun;138(6):1057-62

 

Zhang Y-S, Yuan F-J, Jia G-F, Zhang J-F, Hu L-Y, Huang L,  Wang J, Dai Z-Q
CIK cells from patients with HCC possess strong cytotoxicity to multidrug - resistant cell line Bel-7402 /R. World Journal of Gastroenterology (2005) 11(22):3339-3345.

 

 

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